However, the retrospective study design may have been prone to considerable bias. In addition, more patients who had polyclonal bacteremia died from bacteremia. used the term “polyclonal bacteremia” to describe these episodes of bacteremia.Ī previous retrospective study revealed that patients who had polyclonal gram-negative bacteremia more often had severe underlying conditions than did patients who had monoclonal bacteremia. In some of the later studies, episodes of bacteremia due to >1 genotype of the same species have been described. Modern molecular tools have seldom been used to study sepsis. Therefore, risk factors for the development of sepsis, the natural history of the disease, and especially the therapy have been studied extensively. Gram-negative bacteremia is a serious infection with an estimated crude mortality rate of 20%–50%. Nearly 20% of episodes of bacteremia due to nonfermenting rods were polyclonal, but it remains unclear why nonfermenting rods were more likely to cause polyclonal bacteremia than were other gram-negative rods. However, patients with polyclonal bacteremia received more extensive antibiotic therapy than did patients with monoclonal bacteremia. Complications were equally frequent in all patient groups. Bacteremia due to nonfermenting rods was the single significant risk factor for polyclonal bacteremia. Ten (6.5%) of 153 investigated patients had polyclonal bacteremia. Episodes of bacteremia were considered polyclonal if caused by >1 PFGE type of the same species. For each patient, pulsed field gel electrophoresis (PFGE) was performed on 4 colonies of each morphologic type. We investigated them in a prospective cohort study of patients for whom a blood culture yielded ⩾1 species of gram-negative aerobic rod. It does not store any personal data.The frequency of, risk factors for, and outcome of polyclonal gram-negative bacteremia are still unknown. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category 'Performance'. This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category 'Other.

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Centre for Respiratory Diseases and Meningitis.Centre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses.Centre for Emerging Zoonotic and Parasitic Diseases.

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Gram negative rod bacteria